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Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery

Ningqiang Gong, Wenqun Zhong, Mohamad‐Gabriel Alameh, Xuexiang Han, Lulu Xue, Rakan El‐Mayta, Gan Zhao, Andrew E. Vaughan, Zhiyuan Qin, Fengyuan Xu, Alex G. Hamilton, Dongyoon Kim, Junchao Xu, Junhyong Kim, Xucong Teng, Jinghong Li, Xing‐Jie Liang, Drew Weissman, Wei Guo, Michael J. Mitchell

2024Nature Materials60 citationsDOIOpen Access PDF

Topics & Concepts

NanoparticleDrug deliveryGene knockdownSecretionExtracellularCancer cellSmall interfering RNACellDrug carrierChemistryMicrovesiclesCancer researchBiophysicsNanotechnologyCell biologyCancerBiologyMaterials scienceApoptosisRNABiochemistrymicroRNAGeneGeneticsExtracellular vesicles in diseaseNanoplatforms for cancer theranosticsMicroRNA in disease regulation
Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery | Litcius