Angiokinase inhibition of VEGFR-2, PDGFR and FGFR and cell growth inhibition in lung cancer: Design, synthesis, biological evaluation and molecular docking of novel azaheterocyclic coumarin derivatives
Eman Y. Ahmed, Weam Salah Goda Elserwy, Mohamed F. El‐Mansy, Aya M. Serry, Abdelrahman Salem, Andrew M. Abdou, Basel A. Abdelrahman, Kenzi H. Elsayed, Moaaz R. Abd Elaziz
Topics & Concepts
StaurosporineChemistryCytotoxicityDocking (animal)CoumarinIC50PharmacologyApoptosisEGFR inhibitorsEpidermal growth factor receptorStereochemistryIn vitroBiochemistryKinaseReceptorProtein kinase CBiologyOrganic chemistryMedicineNursingFibroblast Growth Factor ResearchPI3K/AKT/mTOR signaling in cancerCytokine Signaling Pathways and Interactions