Loss of m1acp3Ψ Ribosomal RNA Modification Is a Major Feature of Cancer
Artem Babaian, Katharina Rothe, Dylan Girodat, Igor Minia, Sara Djondovic, Miha Milek, Sandra E. Spencer Miko, Hans‐Joachim Wieden, Markus Landthaler, Gregg B. Morin, Dixie L. Mager
Abstract
Ψ-deficient rRNA forms an uncharacterized class of "onco-ribosome" which may serve as a chemotherapeutic target for treating cancer patients.
Topics & Concepts
Ribosomal RNARNAFeature (linguistics)Computational biologyBiologyCancerGeneticsGenePhilosophyLinguisticsRNA modifications and cancerRNA Research and SplicingRNA and protein synthesis mechanisms