Primary cytotoxic T-cell lymphomas harbor recurrent targetable alterations in the JAK-STAT pathway
Katie Lee, Mark G. Evans, Lei Yang, Spencer Ng, Caroline Snowden, Michael S. Khodadoust, Ryanne A. Brown, Nicholas A. Trum, Christiane Querfeld, Linda Doan, Jinming Song, Hailing Zhang, Alejandro A. Gru, Gary S. Wood, David A. Wada, Vignesh Shanmugam, Paul Haun, Jon C. Aster, Lyn M. Duncan, Joan Guitart, David M. Weinstock, Valentina Nardi, Jaehyuk Choi
Abstract
Primary cytotoxic T cell lymphomas (CTCLs) are a rare subset of aggressive, poor-prognosis T-cell lymphomas targeting the skin; they include primary cutaneous γδT-cell lymphoma, primary cutaneous VD8+ aggressive epidermotropic T cell lymphoma (PCAETCL), and cytotoxic CTCL not otherwise specified. Lee et al report that all 3 subsets have JAK-STAT activation, but PCAETCL uniquely carries JAK2 gene fusions that may render them especially susceptible to JAK inhibitors.