Solid-Phase Synthesis of Boranophosphate/Phosphorothioate/Phosphate Chimeric Oligonucleotides and Their Potential as Antisense Oligonucleotides
Yuhei Takahashi, Kazuki Sato, Takeshi Wada
Abstract
-modification and sugar modification at proper sites of ODNs would control the duplex stability, nuclease resistance, RNase H-inducing ability, and one base mismatch discrimination ability, which are critical properties as potent ASOs.
Topics & Concepts
ChemistryMonomerOligonucleotideChemoselectivityPhosphoramiditePhosphonateNucleaseCombinatorial chemistrySolid-phase synthesisAntisense therapyStereochemistryDNABiochemistryOrganic chemistryPolymerLocked nucleic acidCatalysisPeptideAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryRNA Interference and Gene Delivery