Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells
Frances Kirkham, Alejandra Pera, Amanda M. Simanek, Aalia Bano, George Morrow, Bernhard Reus, Stefano Caserta, Helen Smith, Kevin A. Davies, Chakravarthi Rajkumar, Florian Kern
Abstract
, higher numbers of which are found in CMV+ older people and more so among men than women. Given the high prevalence of CMV worldwide, our findings point to a significant global health issue. Novel strategies to mitigate the increased CVD risk associated with CMV may be required.
Topics & Concepts
SerostatusMedicinePulse wave velocityInternal medicineImmunologyHuman cytomegalovirusBlood pressureViral loadHuman immunodeficiency virus (HIV)VirusCytomegalovirus and herpesvirus researchAtherosclerosis and Cardiovascular DiseasesNeutrophil, Myeloperoxidase and Oxidative Mechanisms