Biomimetic hierarchical implant surfaces promote early osseointegration in osteoporotic rats by suppressing macrophage activation and osteoclastogenesis
Xiaohan Dai, Yunyang Bai, Boon Chin Heng, Yiping Li, Zhangui Tang, Changjian Lin, Ousheng Liu, Ying He, Xuehui Zhang, Xuliang Deng
Abstract
, the implant with a micro/sub-micro hierarchical surface underwent rapid and early osseointegration, with the newly formed bone being tightly integrated with the implants. Hence, the hierarchical surface mitigated the inflammatory microenvironment around the implant, thereby inhibiting osteoclastogenesis. This study thus offers a novel biomimetic strategy for designing surface hierarchical topography to facilitate implant-bone osseointegration in osteoporotic patients.
Topics & Concepts
OsseointegrationMacrophageMaterials scienceImplantNanotechnologyDentistryBiomedical engineeringCell biologyMedicineChemistryBiologyIn vitroBiochemistrySurgeryBone Metabolism and DiseasesBone Tissue Engineering MaterialsBone health and treatments