Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis
Shohei Takaoka, Akiko Yanagiya, Haytham Mohamed Aly Mohamed, Rei Higa, Takaya Abe, Kenichi Inoue, Akinori Takahashi, Patrick N. Stoney, Tadashi Yamamoto
Abstract
-cKO mice. Therefore, we propose that XRN1 function in the hypothalamus is critical for maintenance of metabolic homeostasis.
Topics & Concepts
Energy homeostasisConditional gene knockoutHypothalamusGene knockdownLeptinExoribonucleaseBiologyForebrainHomeostasisEndocrinologyCell biologyGlucose homeostasisInternal medicineKnockout mouseCentral nervous systemNeuroscienceObesityInsulin resistanceRNAMedicinePhenotypeGeneGeneticsRNase PRNA Research and SplicingAdipose Tissue and MetabolismRNA modifications and cancer