Design, synthesis and bioevaluation of novel substituted triazines as potential dual PI3K/mTOR inhibitors
Ting-Ting Wu, Qingqing Guo, Zili Chen, Lili Wang, Lili Wang, Yao Du, Rui Chen, Yuanhu Mao, Sheng‐Gang Yang, Jing Huang, Jianta Wang, Ling Wang, Ling Wang, Lei Tang, Jiquan Zhang
Topics & Concepts
ChemistryPI3K/AKT/mTOR pathwayIC50MTT assayKinaseBenzimidazoleIn vitroPotencyPharmacologyCell growthDiscovery and development of mTOR inhibitorsBiochemistryStereochemistrySignal transductionBiologyOrganic chemistryPI3K/AKT/mTOR signaling in cancerBiochemical and Molecular ResearchSynthesis and Characterization of Heterocyclic Compounds