Discovery of VNRX-7145 (VNRX-5236 Etzadroxil): An Orally Bioavailable β-Lactamase Inhibitor for Enterobacterales Expressing Ambler Class A, C, and D Enzymes
Robert E. Lee Trout, Allison L. Zulli, Eugen F. Mesaros, Randy W. Jackson, Steven A. Boyd, Bin Liu, Jodie C. Hamrick, Denis M. Daigle, Cassandra L. Chatwin, Kaitlyn John, Lisa McLaughlin, Susan M. Cusick, Jason Weiss, Mark Pulse, Daniel C. Pevear, Greg Moeck, L Xerri, Christopher J. Burns
Abstract
restored the activity of the oral cephalosporin antibiotic ceftibuten against Enterobacterales expressing Ambler class A extended-spectrum β-lactamases, class A carbapenemases, class C cephalosporinases, and class D oxacillinases.
Topics & Concepts
ProdrugBioavailabilityChemistryAntibioticsAntimicrobialPharmacokineticsPharmacologyCephalosporinIn vivoMeropenemAntibiotic resistanceBiochemistryMedicineBiologyBiotechnologyOrganic chemistryAntibiotic Resistance in BacteriaAntibiotic Use and ResistanceAntibiotics Pharmacokinetics and Efficacy