A molecular sensor for cholesterol in the human serotonin <sub>1A</sub> receptor
G. Aditya Kumar, Parijat Sarkar, Tomasz Maciej Stępniewski, Md. Jafurulla, Shishu Pal Singh, Jana Selent, Amitabha Chattopadhyay
Abstract
receptor are associated with reduced conformational dynamics of extracellular loops of the receptor. These results constitute one of the first reports on the molecular mechanism underlying cholesterol sensitivity of GPCRs.
Topics & Concepts
Transmembrane domainSerotoninReceptorTransmembrane proteinCholesterolChemistryHelix (gastropod)Residue (chemistry)5-HT receptorCell biologyBiochemistryBiophysicsBiologyEcologySnailReceptor Mechanisms and SignalingLipid Membrane Structure and BehaviorCholesterol and Lipid Metabolism