Synthesis and theoretical calculations of metal-antibiotic chelation with thiamphenicol:<i>in vitro</i>DNA and HSA binding, molecular docking, and cytotoxicity studies
Abeer A. Sharfalddin, Abdul‐Hamid Emwas, Mariusz Jaremko, Mostafa A. Hussien
Abstract
New metal complexes showed the magic of the bivalent metal which have higher bioactivity than free ligand.
Topics & Concepts
ChemistryCytotoxicityChelationIn vitroDocking (animal)MetalThiamphenicolStereochemistryDNAAntibioticsCombinatorial chemistryMolecular modelComputational chemistryBiochemistryChloramphenicolOrganic chemistryNursingMedicineMetal complexes synthesis and propertiesSynthesis and Biological EvaluationDNA and Nucleic Acid Chemistry