The structural basis for Z α <sub>1</sub> -antitrypsin polymerization in the liver
Sarah V. Faull, Emma Elliston, Bibek Gooptu, Alistair M. Jagger, Ibrahim Aldobiyan, Adam Redzej, Magd Badaoui, Nina Heyer‐Chauhan, S. Tamir Rashid, Gary Reynolds, David Adams, Elena Miranda, Elena V. Orlova, James A. Irving, David A. Lomas
Abstract
α 1 -Antitrypsin polymers from human tissue have a structure most consistent with an intermolecular C-terminal domain swap.
Topics & Concepts
PolymerChemistryMonomerMoleculeMutantPolymerizationNegative stainEx vivoBiophysicsBiochemistryElectron microscopeBiologyIn vitroOrganic chemistryGeneOpticsPhysicsVector-borne infectious diseasesCalpain Protease Function and RegulationTrace Elements in Health