H2O2 mediated FLIP and XIAP down-regulation involves increased ITCH expression and ERK-Akt crosstalk in imatinib resistant Chronic Myeloid Leukemia cell line K562
Tamalika Paul, Rajdeep Roy, Rupak Dey Sarkar, Samraj Sinha, Nabendu Biswas
Topics & Concepts
XIAPMAPK/ERK pathwayUbiquitin ligaseProtein kinase BCancer researchCell biologyInhibitor of apoptosisK562 cellsCrosstalkChemistryEctopic expressionPhosphorylationFlipBiologyApoptosisUbiquitinCell cultureProgrammed cell deathBiochemistryCaspaseGenePhysicsGeneticsOpticsCell death mechanisms and regulationProtein Kinase Regulation and GTPase SignalingChronic Myeloid Leukemia Treatments