The Potential Role of Green Tea and its Main Constituent (Epigallocatechin-3-Gallate) in Pain Relief: A Mechanistic Review
Sajad Sahab Negah, Hamed Ghazavi, Farzaneh Vafaee, Roghayeh Rashidi, Ahmad Reza Aminian, Fatemeh Forouzanfar
Abstract
Medicinal plants and dietary supplements may provide an effective and safe treatment for pain relief. Green tea is one of the most common beverages with many several pharmacological activities. The results of various studies have indicated that green tea possesses antinociceptive effects. Many of the protective effects of green tea in terms of pain relief are attributed to its antioxidant and anti-inflammatory properties. Epigallocatechin -3-gallate (EGCG), as one of the major phytochemical components in green tea, is effective in the management of pain through suppression of inflammation and oxidative stress. We have reviewed the effects of green tea on pain and also discussed mechanisms involved in pain relief. This review suggests that green tea can be a safe and often effective treatment for pain.