The effect of QiangGuYin on osteoporosis through the AKT/mTOR/autophagy signaling pathway mediated by CKIP-1
Yifeng Yuan, Jiangang Sun, Hang Zhou, Shen Wang, Caijian He, Tianpeng Chen, Mouhao Fang, Shaohua Li, Shifa Kang, Xiaosheng Huang, Binbin Tang, Bocheng Liang, Yingdelong Mao, Jianyou Li, Xiaolin Shi, Kang Liu
Abstract
confirmed that CKIP-1 interacts with AKT. By up-regulating the expression of Atg5 and down-regulating the p62, the level of LC3 (autophagosome) is increased, and the cells osteogenesis and differentiation are inhibited. QGY inhibits the combination of CKIP-1 and AKT in osteoblasts, activates the AKT/mTOR signaling pathway, inhibits autophagy, and promotes cell differentiation, thereby exerting an anti-osteoporosis effect. Therefore, QGY targeting CKIP-1 to regulate the AKT/mTOR-autophagy signaling pathway may represent a promising drug candidate for the treatment of osteoporosis.