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Calculating degree based multiplicative topological indices of Hyaluronic Acid-Paclitaxel conjugates’ molecular structure in cancer treatment

Akbar Jahanbani, Zehui Shao, Seyed Mahmoud Sheikholeslami

2020Journal of Biomolecular Structure and Dynamics25 citationsDOI

Abstract

A large number of medical experiments have confirmed that the features of drugs have a close correlation with their molecular structure. Drug properties can be obtained by studying the molecular structure of corresponding drugs. The calculation of the topological index of a drug structure enables scientists to have a better understanding of the physical chemistry and biological characteristics of drugs. In this paper, we focus on Hyaluronic Acid-Paclitaxel conjugates which are widely used in the manufacture of anticancer drugs. Several multiplicative topological indices of this molecular structure are determined by using of the edge-partition method.Communicated by Ramaswamy H. Sarma.

Topics & Concepts

PaclitaxelMultiplicative functionHyaluronic acidDegree (music)ConjugateMathematicsTopology (electrical circuits)MedicineCancerInternal medicinePhysicsCombinatoricsMathematical analysisAnatomyAcousticsComputational Drug Discovery MethodsGraph theory and applicationsFree Radicals and Antioxidants
Calculating degree based multiplicative topological indices of Hyaluronic Acid-Paclitaxel conjugates’ molecular structure in cancer treatment | Litcius