Lactose-modified enzyme-sensitive branched polymers as a nanoscale liver cancer-targeting MRI contrast agent
Xiaoqin Zhang, Xiaoming Wang, Zhiqian Li, Jun Du, Xiao Xueyang, Dayi Pan, Hu Zhang, Xiaohe Tian, Qiyong Gong, Zhongwei Gu, Kui Luo
Abstract
MRI results of major organs. Therefore, the branched macromolecule BLDCGd could have great potential as an efficacious and bio-safe nanoscale MRI contrast agent for clinical diagnosis of liver cancer.
Topics & Concepts
Asialoglycoprotein receptorMRI contrast agentChemistryIn vivoMolecular imagingSmall moleculeBiophysicsIn vitroDOTACancer cellTetrapeptideMacromoleculeBiochemistryHepatocyteCancerPeptideGadoliniumChelationBiologyOrganic chemistryBiotechnologyGeneticsNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsLanthanide and Transition Metal Complexes