The role of TFE3 in mediating skeletal muscle mitochondrial adaptations to exercise training
Jenna Wong, Ashley N. Oliveira, Priyanka Khemraj, David A. Hood
Abstract
Our understanding of the role of transcription factor E3 (TFE3) in skeletal muscle is very limited. This research shows that TFE3 plays a direct role in skeletal muscle mitochondrial enhancement with exercise training, thereby introducing a paradigm shift in our perception of the function of TFE3 in mitochondrial maintenance, beyond mitophagy. This research serves to introduce TFE3 as a protein that holds promise as a future therapeutic target for metabolic diseases and skeletal muscle dysfunction.
Topics & Concepts
MitophagyEndurance trainingSkeletal muscleStimulationBiologyMitochondrionEndocrinologyInternal medicineAutophagyCell biologyMedicineBiochemistryApoptosisAutophagy in Disease and TherapyMuscle Physiology and DisordersAdipose Tissue and Metabolism