RIPK3-mediated inflammation is a conserved β cell response to ER stress
Bingyuan Yang, Lisette A. Maddison, Karolina E. Zaborska, Chunhua Dai, Linlin Yin, Zihan Tang, Liqing Zang, David A. Jacobson, Alvin C. Powers, Wenbiao Chen
Abstract
expression in vitro. Furthermore, in human islets grafted in hyperglycemic mice, a marked increase in ER stress, RIPK3, and NF-kB activation in β cells were accompanied with murine macrophage infiltration. Thus, RIPK3-mediated induction of proinflammatory mediators is a conserved, previously unrecognized β cell response to metabolic stress and a mediator of the ensuing islet inflammation.
Topics & Concepts
ZebrafishInflammationIsletFight-or-flight responseUnfolded protein responseCell biologyBiologyInflammatory responseConserved sequenceStress (linguistics)GeneticsImmunologyEndocrinologyGeneInsulinPeptide sequenceEndoplasmic reticulumPhilosophyLinguisticsPancreatic function and diabetesPhagocytosis and Immune RegulationDiabetes and associated disorders