Glucocorticoid receptor-mediated alleviation of inflammation by berberine: <i>in vitro</i>, <i>in silico</i> and <i>in vivo</i> investigations
Yuan Liang, Tiehua Zhang, Jingqi Zhao, Chenfei Li, Haoyang Zou, Fangyu Li, Jie Zhang, Li Ren
Abstract
anti-inflammatory effects of berberine were confirmed in lipopolysaccharide-induced RAW 264.7 cells and in a mouse model of allergic contact dermatitis, respectively. In conclusion, berberine might serve as a potential selective GR modulator.
Topics & Concepts
BerberineIn vivoTransactivationChemistryGlucocorticoid receptorTransrepressionPharmacologyIn vitroIn silicoBiochemistryReceptorBiologyGene expressionGeneBiotechnologyBerberine and alkaloids researchDrug Transport and Resistance MechanismsPhytochemical Studies and Bioactivities