Target protein localization and its impact on PROTAC-mediated degradation
Luke M. Simpson, Lorraine Glennie, Abigail Brewer, Jin‐Feng Zhao, Jennifer Crooks, Natalia Shpiro, Gopal P. Sapkota
Abstract
proteins displayed varying levels of degradation using the same respective PROTACs, suggesting therefore that the subcellular context of the POI can influence the efficacy of PROTAC-mediated POI degradation.
Topics & Concepts
Ubiquitin ligaseEndoplasmic-reticulum-associated protein degradationProtein degradationCell biologyEndoplasmic reticulumContext (archaeology)Subcellular localizationUbiquitinProteasomeGolgi apparatusProteolysisLysosomeDNA ligaseCytoplasmBiologyChemistryBiochemistryUnfolded protein responseEnzymeGenePaleontologyProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis