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Synthesis of an E2-Ub-nucleosome conjugate to capture the E3 ligase PHF7-catalyzed H3K14 ubiquitination intermediate

Shixian Tao, Wei He, Chuntong Li, Jiawei Liang, Zebin Tong, Zhiheng Deng, Liying Zhang, Huasong Ai, Lu-Jun Liang, Lei Liu

2025Science China Chemistry7 citationsDOI

Topics & Concepts

ChemistryUbiquitin ligaseConjugateDNA ligaseUbiquitinCatalysisCell biologyCombinatorial chemistryBiochemistryBiologyDNAMathematical analysisMathematicsGeneUbiquitin and proteasome pathwaysProtein Degradation and InhibitorsPeptidase Inhibition and Analysis
Synthesis of an E2-Ub-nucleosome conjugate to capture the E3 ligase PHF7-catalyzed H3K14 ubiquitination intermediate | Litcius