<i>Lacticaseibacillus paracasei</i> 207-27 alters the microbiota–gut–brain axis to improve wearable device-measured sleep duration in healthy adults: a randomized, double-blind, placebo-controlled trial
Jinxing Li, Jincheng Zhao, Xiaolei Ze, Liang Li, Yapeng Li, Zhimo Zhou, Simou Wu, Wen Jia, Meixun Liu, Yun Li, Xi Shen, Fang He, Ruyue Cheng
Abstract
207-27 administration in healthy adults resulted in improvements in gut microbiota community and sleep duration. The mechanisms might involve modulation of the gut microbiota structure to regulate the function of the gut-brain axis, including increases in SCFA levels and decreases in hypothalamic-pituitary-adrenal axis activity. The Chinese clinical trial registry number is ChiCTR2300069453 (https://www.chictr.org.cn/showproj.html?proj=191193, registered 16 May 2023 - retrospectively registered).
Topics & Concepts
PlaceboSleep (system call)MedicineDuration (music)Gut–brain axisGut floraRandomized controlled trialActigraphyLactobacillus paracaseiAnesthesiaPhysical medicine and rehabilitationInternal medicineBiologyProbioticCircadian rhythmComputer sciencePathologyPhysicsImmunologyOperating systemAcousticsAlternative medicineGeneticsBacteriaGut microbiota and healthObstructive Sleep Apnea ResearchSleep and related disorders