Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation
Mohamed Hagras, Moshira A. El Deeb, Heba S. A. Elzahabi, Eslam B. Elkaeed, Ahmed B. M. Mehany, Ibrahim H. Eissa
Abstract
induced apoptotic effect on HepG-2 thirteen times more than the control cells. To examine the binding pattern of the target compounds against the tubulin heterodimers active site, molecular docking studies were carried out.
Topics & Concepts
Docking (animal)ColchicineChemistryBinding siteStereochemistryEnzymeDrug discoveryPharmacologyCombinatorial chemistryComputational biologyBiochemistryBiologyMedicineGeneticsNursingSynthesis and biological activitySynthesis and Biological EvaluationResearch on Leishmaniasis Studies