Discovery of (S)-N1-(thiazol-2-yl) pyrrolidine-1,2-dicarboxamide derivatives targeting PI3Ka/HDAC6 for the treatment of cancer
Yanfei Zhang, Jin‐Lai Gao, Jiming Wu, Shihui Liu, Xiaoping Zhang, Xiaoqing Lv, Xiaoqing Lv
Topics & Concepts
PyrrolidineChemistryAcetylationHDAC6IC50In vitroPI3K/AKT/mTOR pathwayPharmacologyCancer researchBiochemistryHistone deacetylaseStereochemistryHistoneApoptosisBiologyGeneHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and AnalysisProtein Degradation and Inhibitors