Organocatalytic enantioselective synthesis of C <sub> sp <sub>2</sub> </sub> –N atropisomers <i>via</i> formal C <sub> sp <sub>2</sub> </sub> –O bond amination
Chenxiao Qian, Jing Huang, Tingting Huang, Lijuan Song, Jianwei Sun, Pengfei Li
Abstract
An organocatalyzed asymmetric synthesis of C sp2 –N atropisomers by formal C sp2 –O amination has been established from 3-alkynyl-3-hydroxyisoindolinones and 1-methylnaphthalen-2-ols.
Topics & Concepts
AtropisomerAminationEnantioselective synthesisFormal synthesisChemistryStereochemistryCombinatorial chemistryCatalysisOrganic chemistryAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityAsymmetric Synthesis and Catalysis