Arsenic trioxide-loaded nanoparticles enhance the chemosensitivity of gemcitabine in pancreatic cancer <i>via</i> the reversal of pancreatic stellate cell desmoplasia by targeting the AP4/galectin-1 pathway
Yue Zhao, Hanming Yao, Kege Yang, Shiji Han, Shangxiang Chen, Yaqing Li, Shaojie Chen, Kaihong Huang, Guoda Lian, Jiajia Li
Abstract
) (scAb-ATO-NPs) to promote the delivery efficiency of ATO to PSCs and enhance anti-tumor effects with gemcitabine. Herein, we elucidate the mechanism of how ATO inhibits the activation of PSCs and enhances the therapeutic effect of GEM. We propose a novel cocktail therapy including scAb-ATO-NPs and GEM, indicating a new perspective in the treatment of PDAC.
Topics & Concepts
DesmoplasiaPancreatic cancerGemcitabineChemistryHepatic stellate cellArsenic trioxideCancer researchCancerMedicineInternal medicineApoptosisBiochemistryPancreatic and Hepatic Oncology ResearchPancreatitis Pathology and TreatmentAmoebic Infections and Treatments