Transcranial Doppler microemboli and acute brain injury in extracorporeal membrane oxygenation: A prospective observational study
Giorgio Caturegli, Shrey Kapoor, Vladimir Ponomarev, Bo Soo Kim, Glenn Whitman, Wendy Ziai, Sung‐Min Cho, Lucy Q. Zhang, Yunis Mayasi, Aaron M. Gusdon, Bahattin Ergin, Steven P. Keller, Matthew Acton, Hannah Rando, Diane Alejo, Kate Calligy, Scott Anderson, Benjamin L. Shou, Pedro A. Mendez-Tellez, Henry Chang, Marc Sussman, Christopher Wilcox, Patricia M. Brown, Anna Peeler
Abstract
Objective: Extracorporeal membrane oxygenation (ECMO) carries a high morbidity of acute brain injury (ABI) with resultant mortality increase. Transcranial Doppler (TCD) allows real-time characterization of regional cerebral hemodynamics, but limited data exist on the interpretation of microembolic signals (MES) in ECMO. Methods: This prospective cohort study was conducted at a single tertiary care center, November 2017 through February 2022, and included all adult patients receiving venoarterial (VA) and venovenous (VV) ECMO undergoing TCD examinations, which all included MES monitoring. Results: = .80). In both VA- and VV-ECMO, MES presence or number was not associated with presence of clot or fibrin in the ECMO circuit or with any studied hemodynamic, laboratory, or ECMO parameters at the time of TCD. ABI occurred in 38% and 31.1% of patients on VA- and VV-ECMO, respectively. In multivariable logistic regression analyses, neither ABI nor a composite outcome of arterial thromboembolic events was associated with presence or number of MES in VA- ECMO. Conclusions: TCD analysis in a large cohort of patients on ECMO demonstrates a significant number of MES, especially in patients on VA-ECMO with intra-aortic balloon pump, and/or left ventricular assist device. However, clinical associations and significance of TCD MES remain unresolved and warrant further correlation with systematic imaging and long-term neurologic follow-up.