B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>-catalyzed O–H insertion reactions of diazoalkanes with phosphinic acids
Yangyang Zhang, Xinzhi Zhang, Jincheng Zhao, Jun Jiang
Abstract
A highly efficient base-, metal-, and oxidant-free catalytic O-H insertion reaction of diazoalkanes and phosphinic acids in the presence of B(C6F5)3 has been developed. This powerful methodology provides a green approach towards the synthesis of a broad spectrum of α-phosphoryloxy carbonyl compounds with good to excellent yields (up to 99% yield). The protocol features the advantages of operational simplicity, high atom economy, practicality, easy scalability and environmental friendliness.
Topics & Concepts
CatalysisScalabilityChemistrySimplicityProtocol (science)Combinatorial chemistryStereochemistryPhysicsComputer scienceOrganic chemistryOperating systemPathologyQuantum mechanicsAlternative medicineMedicineCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis