Genetically-targeted photorelease of endocannabinoids enables optical control of GPR55 in pancreatic β-cells
Janelle M. Tobias, Gabriela Rajic, Alexander E. G. Viray, David Icka-Araki, James A. Frank
Abstract
phospholipase C. Moving forward, the OCT-ligand approach can be translated to other ligands and receptors, and will open up new experimental possibilities in targeted pharmacology.
Topics & Concepts
CellChemistryEndocannabinoid systemCell biologyMembraneBiophysicsBiochemistryBiologyReceptorCannabis and Cannabinoid ResearchSleep and Wakefulness ResearchPancreatic function and diabetes