The role of extracellular matrix in the pathophysiology of diabetic wounds
Yaqing Huang, Themis R. Kyriakides
Abstract
Impaired healing leading to the formation of ulcerated wounds is a critical concern in patients with diabetes. Abnormalities in extracellular matrix (ECM) production and remodeling contribute to tissue dysfunction and delayed healing. Specifically, diabetes-induced changes in the expression and/or activity of structural proteins, ECM-modifying enzymes, proteoglycans, and matricellular proteins have been reported. In this review, we provide a summary of the key ECM molecules and associated changes in skin and diabetic wounds. Such information should allow for new insights in the understanding of impaired wound healing and lead to the development of ECM-based therapeutic strategies.
Topics & Concepts
Extracellular matrixPathophysiologyWound healingDiabetes mellitusMatricellular proteinMedicineRegeneration (biology)Cell biologyPathologyBiologyImmunologyEndocrinologyWound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementProteoglycans and glycosaminoglycans research