Vacuolization of hematopoietic precursors: an enigma with multiple etiologies
Carmelo Gurnari, Simona Pagliuca, Lisa Durkin, Laila Terkawi, Hassan Awada, Sunisa Kongkiatkamon, Misam Zawit, Eric D. Hsi, Hetty E. Carraway, Heesun J. Rogers, Valeria Visconte, Jaroslaw P. Maciejewski
Abstract
Cytoplasmic vacuoles in precursors can be seen in a number of clinical settings, including copper deficiency, zinc toxicity, alcohol abuse, antibiotic treatment, myelodysplasia, and VEXAS syndrome. Gurnari et al asked how common VEXAS syndrome is in patients whose bone marrow aspirates show this distinctive feature, finding 2 diagnoses of VEXAS among 24 cases with vacuoles.
Topics & Concepts
VacuolizationEtiologyMedicineHaematopoiesisImmunologyInternal medicineBiologyGeneticsStem cellImmunodeficiency and Autoimmune DisordersHistiocytic Disorders and TreatmentsEosinophilic Disorders and Syndromes