Roles of CCL2-CCR2 Axis in the Tumor Microenvironment
Suguru Kadomoto, Kouji Izumi, Atsushi Mizokami
Abstract
Chemokines are a small family of cytokines that were first discovered as chemotactic factors in leukocytes during inflammation, and reports on the relationship between chemokines and cancer progression have recently been increasing. The CCL2-CCR2 axis is one of the major chemokine signaling pathways, and has various functions in tumor progression, such as increasing tumor cell proliferation and invasiveness, and creating a tumor microenvironment through increased angiogenesis and recruitment of immunosuppressive cells. This review discusses the roles of the CCL2-CCR2 axis and the tumor microenvironment in cancer progression and their future roles in cancer therapy.
Topics & Concepts
Tumor microenvironmentCCR2ChemokineCCL2AngiogenesisTumor progressionChemotaxisCancer researchInflammationBiologyCancerImmunologyChemokine receptorTumor cellsReceptorGeneticsBiochemistryChemokine receptors and signalingImmunotherapy and Immune ResponsesImmune cells in cancer