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6mA-RicePred: A Method for Identifying DNA N6-Methyladenine Sites in the Rice Genome Based on Feature Fusion

Qianfei Huang, Jun Zhang, Leyi Wei, Fei Guo, Quan Zou

2020Frontiers in Plant Science51 citationsDOIOpen Access PDF

Abstract

MOTIVATION: -methyladenine DNA (6mA) in plants is largely unknown. Rice is one of the most important crops worldwide and is a model species for molecular and genetic studies. There are few methods for 6mA site recognition in the rice genome, and an effective computational method is needed. RESULTS: In this paper, we propose a new computational method called 6mA-Pred to identify 6mA sites in the rice genome. 6mA-Pred employs a feature fusion method to combine advantageous features from other methods and thus obtain a new feature to identify 6mA sites. This method achieved an accuracy of 87.27% in the identification of 6mA sites with 10-fold cross-validation and achieved an accuracy of 85.6% in independent test sets.

Topics & Concepts

GenomeComputational biologyFeature (linguistics)Identification (biology)BiologyFusionFunction (biology)Computer sciencePattern recognition (psychology)GeneticsArtificial intelligenceGeneBotanyPhilosophyLinguisticsGenomics and Phylogenetic StudiesMachine Learning in BioinformaticsRNA and protein synthesis mechanisms
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