Fragment-based drug design targeting syntenin PDZ2 domain involved in exosomal release and tumour spread
Manon Garcia, Laurent Hoffer, Raphaël Leblanc, Fatiha Benmansour, Mikaël Feracci, Carine Derviaux, Antonio Luis Egea-Jiménez, Philippe Roche, Pascale Zimmermann, Xavier Morelli, Karine Barral
Topics & Concepts
PDZ domainChemistrySyndecan 1Docking (animal)PeptideSmall moleculeDownregulation and upregulationMicrovesiclesIn vitroIC50DrugDrug discoveryPeptide libraryCell biologyCancer researchComputational biologyBiochemistryPharmacologyCellPeptide sequenceBiologyGeneMedicineNursingmicroRNAHippo pathway signaling and YAP/TAZProtein Degradation and InhibitorsUbiquitin and proteasome pathways