An enzyme-responsive and NIR-triggered lipid–polymer hybrid nanoplatform for synergistic photothermal/chemo cancer therapy
Lu Tang, Qiaqia Xiao, Yue Yin, Yijun Mei, Jing Li, Lin Xu, Hongbin Gao, Wei Wang
Abstract
self-assembled around the hydrophobic complexes to obtain prolonged blood circulation and attenuated systemic toxicity of the hybrid nanosystem. The prepared LP/ID exhibited favourable stability in a physiological environment, good tumor imaging properties, and satisfactory photothermal/chemotherapeutic performance. Moreover, LP/ID could also enhance the cellular uptake and tumor retention capacity in comparison with free drug administration. Notably, by co-loading two therapeutic agents with different anti-cancer mechanisms, an obvious inhibitory effect on tumor growth was observed with negligible damage to normal tissues and organs because of the synergistic photothermal/chemotherapy effect, indicating the great potential of LP/ID as a robust nanoplatform for cancer treatment.