Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth
Bianca J. Lee, Jacob A. Boyer, G. Leslie Burnett, Arun P. Thottumkara, Nidhi Tibrewal, Stacy Wilson, Tientien Hsieh, Abby Marquez, Edward Lorenzana, James Evans, Laura Hulea, Gert Kiss, Hui Liu, Dong Hun Lee, Ola Larsson, Shannon McLaughlan, Ivan Topisirović, Zhengping Wang, Zhican Wang, Yongyuan Zhao, David Wildes, James B. Aggen, Mallika Singh, Adrian L. Gill, Jacqueline A.M. Smith, Neal Rosen
Topics & Concepts
mTORC1ChemistryCell biologyComputational biologyBiochemistryCancer researchBiologyPI3K/AKT/mTOR pathwaySignal transductionPI3K/AKT/mTOR signaling in cancerUbiquitin and proteasome pathwaysCancer Mechanisms and Therapy