Targeted pathological collagen delivery of sustained-release rapamycin to prevent heterotopic ossification
Yangwu Chen, Weiliang Shen, Chenqi Tang, Jiayun Huang, Chunmei Fan, Zi Yin, Yejun Hu, Weishan Chen, Zi Yin, Yi Zhou, Zhengwei Mao, Xiao Chen
Abstract
-glycolic acid) (PLGA) nanoparticles, targeted RAPA specifically to pathological tendon collagen. The CHP-PLGA-RAPA nanoparticles showed excellent pathological collagen affinity, sustained-release ability, and bioactivity. In a mouse model of tendon HO, CHP-PLGA-RAPA nanoparticles specifically bound to pathological tendon and strongly suppressed HO progression. The mTOR signaling pathway appears to be a viable therapeutic target for tendon HO, and CHP-PLGA nanoparticles may be valuable for the treatment of tendon-related diseases.
Topics & Concepts
Heterotopic ossificationPathologicalOssificationMedicinePathologyCancer researchChemistryAnatomyHeterotopic Ossification and Related ConditionsCervical and Thoracic Myelopathy