Xeno-free cultured mesenchymal stromal cells release extracellular vesicles with a “therapeutic” miRNA cargo ameliorating cartilage inflammation <i>in vitro</i>
Maria Elisabetta Federica Palamà, Simona Coco, Georgina Shaw, Daniele Reverberi, Maddalena Ghelardoni, Paola Ostano, Giovanna Chiorino, Laura Sercia, Luana Persano, Maria Cristina Gagliani, Katia Cortese, Dario Pisignano, Josephine Mary Murphy, Chiara Gentili
Abstract
XFS medium was found to be suitable for isolation and expansion of MSCs, secreting EVs with a therapeutic cargo. The application of cells cultured exclusively in XFS overcomes issues of safety associated with serum-containing media and makes ready-to-use clinical therapies more accessible.
Topics & Concepts
Mesenchymal stem cellCell biologyStromal cellParacrine signallingChemistryIn vitroDownregulation and upregulationPlatelet lysateOxygen tensionCartilageBone marrowInflammationCancer researchImmunologyBiologyBiochemistryAnatomyGeneOrganic chemistryOxygenReceptorExtracellular vesicles in diseaseMicroRNA in disease regulationCircular RNAs in diseases