Peptide epitope-imprinted polymer microarrays for selective protein recognition. Application for SARS-CoV-2 RBD protein
Zsófia Bognár, Eszter Supala, Aysu Yarman, Xiaorong Zhang, Frank F. Bier, Frieder W. Scheller, Róbert E. Gyurcsányi
Abstract
We introduce highly affine epitope-imprinted polymer-based microarrays for selective protein detection by surface plasmon resonance imaging as shown through the selective recognition of the receptor binding domain of SARS-CoV-2 spike protein.
Topics & Concepts
ChemistryMolecularly imprinted polymerPeptideSurface plasmon resonanceEpitopeDNA microarrayAptamerMolecular imprintingProtein Array AnalysisBiophysicsCombinatorial chemistryBiochemistryMolecular biologyNanoparticleNanotechnologyMaterials scienceAntibodyBiologyGeneGene expressionSelectivityCatalysisImmunologyBiosensors and Analytical DetectionSARS-CoV-2 detection and testingAdvanced biosensing and bioanalysis techniques