Structural and mechanistic insights into peptidylarginine deiminase (PAD2/PAD4) mediated citrullination and therapeutic targeting: A review
Fareeha Bashir, Hina Awais, Arooj Waseem, Aqsa Shahzad, Aiman Babar, Syed Ahmad Ali, Laiba Shafiq, Moiz Ahmed Bhatti
Topics & Concepts
CitrullinationEpigeneticsChemistryAutoimmunityChromatinImmune systemComputational biologyMechanism (biology)Cell biologyHistoneRational designGene isoformBiologyProtein structureTranscription factorProtein–protein interactionAcetylationProtein foldingBiochemistryStructural biologyRegulation of gene expressionAutoimmune diseaseNeutrophil, Myeloperoxidase and Oxidative MechanismsRheumatoid Arthritis Research and TherapiesCell Adhesion Molecules Research