Therapeutic potential of garlic chive-derived vesicle-like nanoparticles in NLRP3 inflammasome-mediated inflammatory diseases
Baolong Liu, Xingzhi Li, Han Vit Yu, Xuan Shi, You Zhou, Sophie Alvarez, Michael J. Naldrett, Stephen D. Kachman, Seung‐Hyun Ro, Xinghui Sun, Soonkyu Chung, Lili Jing, Jiujiu Yu
Abstract
Identification of GC-VLNs and their active component DLPC as potent inflammasome inhibitors provides new therapeutic candidates in the treatment of NLRP3 inflammasome-driven diseases.
Topics & Concepts
InflammasomePyrin domainInflammationChemistryPharmacologyCell biologyBiochemistryMedicineBiologyImmunologyInflammasome and immune disordersCholesterol and Lipid MetabolismSphingolipid Metabolism and Signaling