Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity
Zonghui Ma, Ling Jiang, Bingyan Li, Dailin Liang, Feng Yu, Li Liu, Cheng Jiang
Topics & Concepts
ChemistryAldehyde dehydrogenaseBenzimidazoleMetforminALDH2PharmacologyIn vitroBiochemistryMetabolic stabilityEnzymeDiabetes mellitusEndocrinologyBiologyOrganic chemistryMetabolomics and Mass Spectrometry StudiesAlcohol Consumption and Health EffectsChromatography in Natural Products