Thymoquinone-loaded lipid nanocapsules with promising anticancer activity for colorectal cancer
Mouna Selmi, Abir Salek, Mahassen Barboura, Leïla Njim, Amine Trabelsi, Aida Lahmar, Nolwenn Lautram, Emilie Roger, Tarek Baâti, Leila Chekir Ghedira
Abstract
studies showed that the intratumoral administration of TQ-LNCs decreased the tumor size in colorectal cancer bearing mice compared to the control group. TQ-LNCs were more effective than free TQ for inducing tumor cell death. These results highlight the potential of TQ entrapped in LNCs as an anticancer agent for CRC treatment.
Topics & Concepts
ThymoquinoneNanocarriersColorectal cancerNanocapsulesIn vivoMedicinePharmacologyApoptosisNigella sativaChemotherapyCancerCancer researchChemistryDrugInternal medicineTraditional medicineAntioxidantBiologyNanotechnologyBiochemistryMaterials scienceBiotechnologyNanoparticleNigella sativa pharmacological applicationsNanoparticle-Based Drug DeliveryBioactive Compounds and Antitumor Agents