Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis
Hui Huang, Jie Xue, Tao Xie, Mei-Lin Xie
Topics & Concepts
AMPKPI3K/AKT/mTOR pathwayProtein kinase AIntracellularGlycolysisChemistryRadiosensitivityGSK-3AMP-activated protein kinasePKM2DNA damagePyruvate kinaseCell biologyCancer researchKinaseSignal transductionBiologyBiochemistryInternal medicineMedicineMetabolismDNARadiation therapyGenomics, phytochemicals, and oxidative stressPI3K/AKT/mTOR signaling in cancerPlant chemical constituents analysis