Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity
Jing Ni, Xi Wang, Ana Stojanovic, Qin Zhang, Marian Wincher, Lea Bühler, Annette Arnold, Margareta P. Correia, Manuel Winkler, Philipp‐Sebastian Koch, Veronika Sexl, Thomas Höfer, Adelheid Cerwenka
Topics & Concepts
BiologyHIF1ACancer researchNatural killer cellTranscription factorCellNK-92Lymphokine-activated killer cellTumor necrosis factor alphaEffectorInterleukin 12Interleukin 21Immune systemCell biologyImmunologyT cellAngiogenesisCytotoxic T cellGeneGeneticsBiochemistryIn vitroImmune Cell Function and InteractionImmune cells in cancerIL-33, ST2, and ILC Pathways