Rollover Cyclometalation vs Nitrogen Coordination in Tetrapyridyl Anticancer Gold(III) Complexes: Effect on Protein Interaction and Toxicity
Xue‐Quan Zhou, Imma Carbo‐Bague, Maxime A. Siegler, Jonathan Hilgendorf, Uttara Basu, Ingo Ott, Rongfang Liu, Liyan Zhang, Vadde Ramu, Adriaan P. IJzerman, Sylvestre Bonnet
Abstract
ions that were taken up in minute amounts in the cytosol, and a toxic tetrapyridyl ligand also capable of binding to hERG. These results demonstrate that bis-cyclometalation is an appealing method to improve the redox stability of Au(III) compounds and to develop gold-based cytotoxic compounds that do not rely on TrxR inhibition to kill cancer cells.
Topics & Concepts
ChemistryThioredoxin reductaseLigand (biochemistry)ProtonationDeprotonationStereochemistryMetalAmine gas treatingMedicinal chemistryGold CompoundsDimerCrystallographyThioredoxinCombinatorial chemistryIonOrganic chemistryOxidative stressReceptorBiochemistryMetal complexes synthesis and propertiesOrganometallic Complex Synthesis and CatalysisMetal-Catalyzed Oxygenation Mechanisms