PLK1 is required for chromosome compaction and microtubule organization in mouse oocytes
Tara M. Little, Philip W. Jordan
Abstract
cKO oocytes either failed to organize α-tubulin or developed an abnormally small bipolar spindle. These abnormalities were attributed to aberrant release of the microtubule organizing center (MTOC) linker protein, C-NAP1, and the failure to recruit MTOC components and liquid-like spindle domain (LISD) factors. Ultimately, these defects result in meiosis I arrest before homologous chromosome segregation.
Topics & Concepts
PLK1BiologyCell biologyPolo-like kinaseMicrotubule organizing centerMeiosisGeneticsCentrosomeCell cycleCellGeneMicrotubule and mitosis dynamicsReproductive Biology and FertilityPrenatal Screening and Diagnostics