Astrocyte and ions metabolism during epileptogenesis: A review for modeling studies*
Mengmeng Du, Jiajia Li, Zhixuan Yuan, Yongchen Fan, Ying Wu
Abstract
As a large group of cells in a central nervous system, astrocytes have a great influence on ion and energy metabolism in a nervous system. Disorders of neuronal ion and energy metabolism caused by impaired astrocytes play a key role in the pathogenesis of epilepsy. This paper reviews the existing computational models of epileptogenesis resulting from impaired astrocytes and presents several open perspectives with regard to ion and energy metabolism-induced epileptogenesis in a neuron-astrocyte-capillary coupled model.
Topics & Concepts
EpileptogenesisAstrocyteNeuroscienceEpilepsyNervous systemEnergy metabolismMetabolismNeuronCentral nervous systemMedicineBiologyEndocrinologyNeuroscience and Neuropharmacology ResearchEpilepsy research and treatmentLipid Membrane Structure and Behavior